{"id":1838,"date":"2025-03-23T20:33:38","date_gmt":"2025-03-23T20:33:38","guid":{"rendered":"https:\/\/uthink.studio\/?p=1838"},"modified":"2025-03-25T20:02:06","modified_gmt":"2025-03-25T20:02:06","slug":"anticancer-moa-illustration","status":"publish","type":"post","link":"https:\/\/uthink.studio\/zh\/anticancer-moa-illustration\/","title":{"rendered":"\u6297\u764c\u85e5\u7269\uff1a3D \u85e5\u7269\u6a5f\u5236\u63d2\u5716"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1838\" class=\"elementor elementor-1838\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-29f619cd e-flex e-con-boxed e-con e-parent\" data-id=\"29f619cd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4030bac e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"4030bac\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-85206bd e-con-full e-flex e-con e-child\" data-id=\"85206bd\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a129ec elementor-widget elementor-widget-heading\" data-id=\"5a129ec\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Message<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-179799e elementor-widget elementor-widget-text-editor\" data-id=\"179799e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>ABCG2-Q141K is a common type of transmembrane transporter variant. Many anticancer drugs are substrates of ABCG2 protein. Understanding why ABCG2-Q141k affects anticancer drug concentration in plasma may be the key to improving treatment performance in patients with genetic variants. This two-page spread aims to\u00a0<strong>assist the biomedical professional audience in understanding the structure and trafficking defect of ABCG2-Q141K.<\/strong>\u00a0The combination of 2D and 3D visualization with\u00a0<strong>color-coding<\/strong>\u00a0magnifies the clarity of information. The single nucleotide was modified in Swiss-Model by using the PDB file as a template to present an accurate structure of the variant.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2de9f95 e-con-full e-flex e-con e-child\" data-id=\"2de9f95\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-624f958 e-grid e-con-full e-con e-child\" data-id=\"624f958\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4ce8110 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"4ce8110\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInRight&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c6281ee elementor-widget elementor-widget-heading\" data-id=\"c6281ee\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Client<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c78d9a0 elementor-widget elementor-widget-text-editor\" data-id=\"c78d9a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Pharma<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b790473 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"b790473\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;slideInRight&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-03ff0ef elementor-widget elementor-widget-heading\" data-id=\"03ff0ef\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u670d\u52d9\u9805\u76ee<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c764c4 elementor-widget elementor-widget-text-editor\" data-id=\"4c764c4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>3D modeling<\/li><li>Molecular Visualization<\/li><li>Schematic Illustration<\/li><li>Graphic Design<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d6c8423 e-con-full e-flex e-con e-child\" data-id=\"d6c8423\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4c18e7d e-con-full e-flex e-con e-child\" data-id=\"4c18e7d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-958f1c6 elementor-widget elementor-widget-heading\" data-id=\"958f1c6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Final Deliverables<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d60918 elementor-widget elementor-widget-text-editor\" data-id=\"1d60918\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Combining 2D and 3D elements with color-coded clarity, the piece helps professionals understand how this common transporter variant may impact anticancer drug levels in patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d051810 e-con-full animated-slow e-flex elementor-invisible e-con e-child\" data-id=\"d051810\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-08672e2 elementor-widget elementor-widget-image\" data-id=\"08672e2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink.jpg\" data-elementor-open-lightbox=\"yes\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjExMCwidXJsIjoiaHR0cHM6XC9cL3V0aGluay5zdHVkaW9cL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzAzXC9BQkNHLVByb3RlaW4tM2QtaWxsdXN0cmF0aW9uX0Z1bGxfVVRoaW5rLmpwZyJ9\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1242\" src=\"https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink.jpg\" class=\"attachment-full size-full wp-image-2110\" alt=\"\" srcset=\"https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink.jpg 1920w, https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink-300x194.jpg 300w, https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink-1024x662.jpg 1024w, https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink-768x497.jpg 768w, https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink-1536x994.jpg 1536w, https:\/\/uthink.studio\/wp-content\/uploads\/2025\/03\/ABCG-Protein-3d-illustration_Full_UThink-18x12.jpg 18w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u96d9\u9801\u5f0f\u751f\u7269\u91ab\u5b78\u63d2\u5716\uff0c\u8996\u89ba\u5316\u5448\u73fe ABCG2-Q141K \u7a81\u8b8a\u682a\u7684\u7d50\u69cb\u8207\u904b\u8f38\u7570\u5e38\u6a5f\u5236\u3002<\/p>","protected":false},"author":1,"featured_media":1805,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,26],"tags":[32],"class_list":["post-1838","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-illustration","category-work","tag-pharma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/posts\/1838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/comments?post=1838"}],"version-history":[{"count":6,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/posts\/1838\/revisions"}],"predecessor-version":[{"id":2113,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/posts\/1838\/revisions\/2113"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/media\/1805"}],"wp:attachment":[{"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/media?parent=1838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/categories?post=1838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/uthink.studio\/zh\/wp-json\/wp\/v2\/tags?post=1838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}